EB blisters should be drained if they are tense or are ½ inch in diameter or larger, because the fluid inside the blister puts pressure on the surrounding skin. This pressure causes the skin layers to split further and results in a larger blister. A larger blister is more painful, takes longer to heal and is at greater risk for infection. When draining a blister, the side of the blister roof should be punctured using a sterile needle, lancet or manicure scissors. If using a needle, be sure the opening in the blister is large enough that it will not seal and refill. Every effort should be made to leave the blister roof in place, as this aids wound healing and reduces pain.