Many people with EB can wear regular clothing without developing blisters. However, clothing tags should be removed and clothing with tight elastic should be avoided. Soft, loose-fitting clothing is best for delicate EB skin. For those with particularly delicate skin, clothes may be worn inside-out so that the seams are on the outside of the clothing, where they will not irritate the skin and cause blistering.
Other helpful modifications to regular clothing include removal of the collar and cuffs from shirts. When these efforts do not prove to be successful, the use of bandages or soft cotton undergarments (t-shirts, leggings) may be necessary to protect the skin.