EB lesions are painful. Covering the areas with ointments and bandages provides the most effective relief. Having assistance available and working fast is helpful. Medicating the baby before dressing changes and baths is common. Using a non-sedating medication (with a physician’s order), such as acetaminophen or ibuprofen, may be helpful. Narcotic medications (such as morphine) are used when needed but often are avoided because they affect the child's ability to stay awake and take in adequate calories. When such medications are necessary, parents should try to time the dose to minimize the impact on feeding.