Spontaneous Mutation

EB also can be acquired through a new or spontaneous mutation. That is, a child is born with a dominant genetic mutation that causes EB, despite neither parent having EB. When this occurs, it is because the gene spontaneously mutated in either the sperm or the egg before conception. Once the child has a dominant gene for EB, he or she has a 50 percent chance of passing the disorder to his or her children, as explained above. There is no scientific evidence that the parents could have prevented such spontaneous mutation, and there are no known environmental, dietary or behavioral triggers for this type of mutation.